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近年来对各种具有细胞毒性的淋巴细胞及其细胞表面分子、靶细胞特异性、激活条件以及在疾病发生中的作用,获得了很多新的知识.已知有一种淋巴细胞在预先未免疫的情况下,能够在体外溶解大多数培养细胞株、造血细胞和肿瘤细胞.该细胞称为自然杀伤细胞(NK),是一种比较匀一的大颗粒淋巴细胞,具有Fe受体:此受体仅能与聚集的或复合的免疫球蛋白结合.NK细胞可被较专一的单克隆抗体Leu-11所认别.另一种单克隆抗体HNK-1(Leu-7)也能与某些NK作用,但同时与其他一些淋巴细胞相作用,所以不是NK特异的标志.绝大多数NK细胞并无OKT-3、OKT-4和
In recent years, a lot of new knowledge has been gained about various cytotoxic lymphocytes and their cell surface molecules, target cell specificity, activation conditions, and their role in disease development. It is known that there is a type of lymphocyte that is not previously immunized. In the case of in vitro dissolution of most cultured cell lines, hematopoietic cells and tumor cells. This cell is called natural killer (NK) cells and is a relatively uniform large granular lymphocyte with Fe receptors: this receptor Can only bind to aggregated or complex immunoglobulins. NK cells can be identified by the more specific monoclonal antibody Leu-11. Another monoclonal antibody HNK-1 (Leu-7) can also be associated with certain The role of NK, but at the same time with some other lymphocytes, so it is not a sign of NK specific. The vast majority of NK cells do not have OKT-3, OKT-4 and