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目的探讨老年恶性血液病患者合并感染的特点,分析感染的因素,采取有效措施降低感染发生率。方法对我院1992年2月~2005年10月住院的82例恶性血液病病例进行回顾性临床分析。结果发生感染患者70例,感染率85.4%,入院时即合并感染44例,感染率53.7%,医院感染26例,感染率31.7%,院内感染50例次,感染例次率61.0%。感染部位以呼吸道为首位,口腔感染亦常见,其次为尿路感染、肠道感染。以革兰阴性菌感染为主,占56%。结论老年恶性血液病感染发生率高,易感因素为老年疾病本身、生理屏障受损、合并慢性病、脏器功能衰退、中性粒细胞减少及自身免疫功能低下,还与化疗有关。预防和控制感染是提高疗效、延长患者生存期的重要因素。
Objective To investigate the characteristics of co-infection in elderly patients with hematological malignancies, analyze the factors of infection and take effective measures to reduce the incidence of infection. Methods A retrospective clinical analysis of 82 cases of hematological malignancies hospitalized from February 1992 to October 2005 in our hospital. Results Infection occurred in 70 patients, the infection rate was 85.4%. At the time of admission, 44 patients were infected with infection, the infection rate was 53.7%. The hospital infection was 26, the infection rate was 31.7%, the nosocomial infection rate was 50, and the infection rate was 61.0%. Infected parts of the respiratory tract as the first, oral infections are common, followed by urinary tract infections, intestinal infections. Gram-negative bacteria infection, accounting for 56%. Conclusions The incidence of hematologic malignancies in elderly patients is high. The predisposing factors are elderly patients themselves, impaired physiological barriers, chronic diseases, organ dysfunction, neutropenia and autoimmune diseases. Chemotherapy is also involved. Prevention and control of infection is to improve the efficacy and prolong survival of patients an important factor.