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目的检测胸腹部创伤病人外周血中白细胞介素-12(IL-12)的水平,并评估其临床意义。方法采用双抗体夹心酶联免疫吸附测量法检测77例胸腹部损伤病人外周血中 IL-12的水平,35例健康者作为正常对照组。结果严重胸腹部创伤病人(ISS 评分≥16分)外周血 IL-12水平组比轻度创伤(ISS<16分)明显增高(P<0.05)。两组均明显高于正常对照组(P<0.05)。伤后并发全身炎症反应综合征(SIRS)和多器官功能不全综合征(MODS)的病人,IL-12的水平较非 SIRS 和 MODS 的病人显著增高(P<0.05)。结论胸腹创伤后外周血中IL-12的变化与创伤严重程度相平行。其检测对伤情的判断具有重要的临床意义,对创伤后并发 SIRS 和 MODS 有重要的预警价值。
Objective To detect the level of interleukin-12 (IL-12) in the peripheral blood of thoracoabdominal trauma patients and to evaluate the clinical significance. Methods The levels of IL-12 in peripheral blood of 77 patients with thoracoabdominal injuries were detected by double antibody sandwich enzyme-linked immunosorbent assay (ELISA), and 35 healthy controls were used as normal control. Results Serum levels of IL-12 in peripheral blood of patients with severe thoracoabdominal trauma (ISS score≥16) were significantly higher than those of mild trauma (ISS <16 scores) (P <0.05). Both groups were significantly higher than the normal control group (P <0.05). In patients with systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) after injury, IL-12 levels were significantly higher (P <0.05) than those without SIRS and MODS. Conclusion The changes of IL-12 in peripheral blood after the traumatic abdominal injury are in parallel with the severity of trauma. The detection of the judgment of the injury has important clinical significance, the post-traumatic complicated with SIRS and MODS have important early warning value.