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目的观察地奈德乳膏联合多润皮肤护理剂治疗慢性湿疹的疗效。方法将78例门诊就诊的慢性湿疹患者简单随机抽样分为治疗组和对照组,治疗组42例外用地奈德乳膏(重庆华邦制药有限公司)和多润皮肤护理剂(济南蓝科医学工程有限公司),每天各2次,对照组36例外用地奈德乳膏,2次/d,2组均使用4周。治疗前后对部位、症状及皮损面积的总积分按EASI评分进行评价。治疗过程中观察并记录药物的不良反应。2个月后对治愈的患者进行复发率的随访。结果治疗组42例中痊愈28例,显效10例;对照组36例中痊愈15例,显效9例,2组疗效比较差异有统计学意义(Z=-2.759,P<0.05)。对治愈病例2个月后随访复发率,治疗组28例治愈中有2例复发,复发率为7.1%,对照组15例治愈中有5例复发,复发率为33.3%,2组复发率比较差异有统计学意义(P<0.05)。治疗组与对照组均未见明显不良反应。结论地奈德乳膏联合多润皮肤护理剂治疗慢性湿疹有较好疗效,安全性较高。
Objective To observe the curative effect of the combination of earth-nude cream and Duorun skin care on chronic eczema. Methods A total of 78 patients with chronic eczema who were diagnosed as outpatients were randomly divided into treatment group and control group. Forty-two patients in treatment group were treated with Rhodiola cream (Chongqing Huabang Pharmaceutical Co., Ltd.) and Du Run Run Skin Care (Jinan Lanke Medical Engineering Co., Ltd.), twice a day, control group of 36 cases of external use of Ned Cream, 2 times / d, 2 groups were used for 4 weeks. The total score of the area, the symptom and the lesion area before and after treatment was evaluated according to the EASI score. During treatment, observe and record adverse drug reactions. Follow-up of the recurrence rate of the cured patients after 2 months. Results Among the 42 cases in the treatment group, 28 cases were cured and 10 cases were markedly effective. In the control group, 15 cases were cured and 9 cases were markedly effective. The difference between the two groups was statistically significant (Z = -2.759, P <0.05). Two months after the cure, the recurrence rate of follow-up was 28 cases in the treatment group, and the recurrence rate was 7.1%. In the control group, 5 cases were cured and the recurrence rate was 33.3%. The recurrence rate was significantly higher in the two groups The difference was statistically significant (P <0.05). No significant adverse reactions were found in the treatment group and the control group. Conclusion The combination of earth-nude cream and multi-moisturizing skin care for chronic eczema has good curative effect and high safety.