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利用转基因植物生产重组蛋白并不能解决所有蛋白的生产问题。是否选择这种方法很大程度上取决于所要生产的蛋白种类及用途。许多蛋白用传统微生物发酵的方法可以得到最好的效果。同样,某些蛋白质利用植物生产是唯一可行的办法。为了挖掘转基因植物作为蛋白生产系统的最大潜力,更好地了解植物蛋白折叠、组装和加工的细胞机理至关重要。植物作为表达系统的主要优点之一是,植物属于具有内膜系统的高等真核生物,因此能够利用与哺乳动物同源的侣伴蛋白对重组蛋白进行折叠加工及翻译后修饰。这就使植物能被用来生产单克隆抗体及其他各种免疫球蛋白分子和多聚复合体。
The use of transgenic plants to produce recombinant proteins does not solve all protein production problems. Whether to choose this method depends very much on the type of protein to be produced and its use. Many proteins are fermented using traditional microorganisms to get the best results. Similarly, the use of certain proteins for plant production is the only viable option. In order to tap the potential of genetically modified plants as a protein production system, it is important to understand the cellular mechanisms of plant protein folding, assembly and processing. One of the major advantages of plants as an expression system is that the plants belong to the higher eukaryotes with an intima system and therefore are capable of folding and post-translational modification of recombinant proteins using chaperone proteins homologous to mammals. This allows plants to be used to produce monoclonal antibodies and various other immunoglobulin molecules and multimeric complexes.