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[目的]探讨蒙脱石对防治阿奇霉素所致胃肠道反应的疗效。[方法]将100例支原体肺炎、急性扁桃体炎患儿随机分为治疗组60例和对照组40例。两组均给予阿奇霉素,按体重5～10mg/kg,加入5%葡萄糖溶液100mL或250mL,同时加入维生素B_650～100mg,然后静脉滴注,滴注时间为2～3h,每日1次疗程均为5天。治疗组在治疗前半小时另加蒙脱石口服,每次2～3g,用温开水稀释摇匀后服下。观察两组治疗后胃肠道反应的情况。[结果]治疗组控制胃肠道反应的总有效率100%(60/60),对照组控制胃肠道反应的总有效率87.5%(35/40)。两组比较差异有统计学意义(均为P<0.05)。[结论]蒙脱石防治阿奇霉素所致胃肠道反应疗效确切。
[Objective] To investigate the effect of montmorillonite on the prevention and treatment of azithromycin-induced gastrointestinal reactions. [Method] 100 cases of mycoplasma pneumonia and acute tonsillitis were randomly divided into treatment group (60 cases) and control group (40 cases). Both groups were given azithromycin, according to the weight of 5 ~ 10mg / kg, adding 5% glucose solution 100mL or 250mL, while adding vitamin B_650 ~ 100mg, and then intravenous infusion, infusion time of 2 ~ 3h, 1 day course were 5 days. The treatment group plus montmorillonite half an hour before treatment, each 2 ~ 3g, diluted with warm water, shake and take the next. After treatment, the gastrointestinal reactions were observed. [Results] The total effective rate of the control group was 100% (60/60) for controlling gastrointestinal reactions and 87.5% (35/40) for the control group. The difference between the two groups was statistically significant (both P <0.05). [Conclusion] The montmorillonite is effective in preventing and treating the gastrointestinal reaction caused by azithromycin.