现代中医学认为,“肾为先天之本”与基因遗传特异相关,肾虚为先天遗传性疾病的关键病机,补肾是先天遗传性疾病关键而独特的防治手段。目前,常见的单基因遗传性脑血管疾病常染色体显性遗传性脑动脉病伴皮质下梗死和白质脑病(CADASIL)缺乏特异性治疗手段,严重危害国民健康。基于“肾为先天之本”探索CADASIL的发病机制、防治策略合理、可行,对保障国民身心健康发展、维护家庭与社会和谐稳定具有重要意义。 Modern Chinese medicine believes that “kidney is the birth of the ” and genetic specific genetically related to kidney deficiency is the key pathogenesis of congenital genetic diseases, kidney is a key and unique control of congenital genetic diseases. Currently, the common single-gene hereditary cerebrovascular disease, autosomal dominant cerebral artery disease with subcortical infarction and leukoencephalopathy (CADASIL) the lack of specific treatment, seriously endangering national health. To explore the pathogenesis of CADASIL based on “Kidney as the foundation of innateness ”, the prevention and cure strategy is reasonable and feasible, which is of great significance to safeguarding the healthy development of people’s mind and body and maintaining the harmony and stability of family and society.