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目的:探讨肠泻停胶囊对三硝基苯磺酸(TNBS)诱导大鼠实验性结肠炎的影响。方法:120只SD大鼠随机分为6组,每组20只:正常组、模型组、阳性对照组、肠泻停胶囊高、中、低组。除正常对照组未行造模外,其余五组大鼠均采用TNBS造模。肠泻停胶囊高、中、低组分别灌胃给药(1.80,0.90,0.45 g/kg体质量)、阳性对照组灌胃给予地塞米松剂量(0.2 mg/kg体质量)、其余组灌胃给予0.5%羧甲基纤维素钠溶液连续3周、4周;观察肠泻停胶囊对大鼠腹泻率、死亡率、血白细胞计数、淋巴细胞百分率、脾脏及胸腺重量、组织形态学评分、组织MPO活性的影响。结果:经肠泻停胶囊干预后各剂量组动物腹泻明显缓解,腹泻率降低,动物死亡率降低,外周血WBC、LYM值及组织MPO值降低,剖检可见结肠组织溃疡面积明显缩小,水肿缓解,坏死减轻,未见肠壁增厚。结论:肠泻停胶囊连续给药,对实验性结肠炎治疗作用显著。
Objective: To investigate the effect of Enteric Capsule on experimental colitis induced by trinitrobenzene sulfonic acid (TNBS) in rats. Methods: One hundred and twenty SD rats were randomly divided into 6 groups with 20 rats in each group: normal group, model group, positive control group, high, medium and low groups of enteric capsules. In addition to the normal control group without modeling, the other five groups of rats were used TNBS modeling. The patients in high, middle and low groups of gut capsule were intragastrically administrated (1.80,0.90,0.45 g / kg body weight), the positive control group was given dexamethasone dose (0.2 mg / kg body weight) The stomach was given 0.5% sodium carboxymethyl cellulose solution for 3 consecutive weeks, 4 weeks; observed diarrhea Sagi Capsule on rat diarrhea rate, white blood cell count, lymphocyte percentage, spleen and thymus weight, histological score, Effect of tissue MPO activity. Results: The diarrhea rate, the diarrhea rate and the mortality rate of animals in each dose group were significantly decreased after the intervention of Zhimixipai Capsule. The WBC and LYM values in peripheral blood and the MPO level in the peripheral blood were decreased. The ulcer area in the colon tissue was significantly reduced and edema was relieved , Reduce necrosis, no intestinal wall thickening. Conclusion: Enteric capsules are administered continuously and have a significant therapeutic effect on experimental colitis.