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为了从神经元水平探讨大脑皮层内脏伤害感受的特性及机制 ,应用玻璃微电极细胞内电位记录技术 ,研究 18只猫扣带回前部 312个神经元的自发生物电活动 ,及其对电刺激同侧内脏大神经的诱发反应 .其中 ,82个为内脏伤害感受神经元 ,其自发生物电活动有 5种主要形式 .根据诱发反应的潜伏期等特性 ,内脏伤害感受神经元分为特异性内脏伤害感受神经元 (76个 ,92 6 8% )和非特异性内脏伤害感受神经元 (6个 ,7 32 % ) .内脏伤害性诱发反应分为兴奋性 (6 5 86 % )、抑制性 (17 0 7% )及混合性反应 (17 0 7% ) 3种 .结果提示内脏大神经的传入通路投射到同侧扣带回前部 ;扣带回前部神经元具有内脏伤害感受作用 ,存有特异性与非特异性内脏伤害感受神经元 ,为痛觉特异性学说提供了新的实验依据
In order to explore the characteristics and mechanism of visceral nociception in the cerebral cortex from the neuron level, the spontaneous bioelectrical activity of 312 neurons in the front part of 18 cats was studied by using the intracellular potential recording technique of glass microelectrode. The visceral nociceptive neurons were induced in 82 cases, of which 82 were visceral nociceptive neurons and their spontaneous bioelectrical activities had 5 main forms.According to the characteristics such as latency of evoked reaction, visceral nociceptive neurons were divided into specific visceral injuries Sensory neurons (76, 92.68%) and nonspecific visceral nociceptive neurons (6, 732%) were classified into excitatory (65.86%) and inhibitory 7%) and mixed reaction (17 0 7%). The results suggest that the afferent pathway of the visceral large nerves project to the anterior side of the ipsilateral cingulate gyrus; the anterior cingulate neurons have visceral nociception, Specific and nonspecific visceral nociceptive neurons provide new experimental evidence for the pain-specific theory