胰岛素通过胃肠道途径给药的方法,由于其具有潜在的临床价值,曾有人作了若干努力。当时,采用口腔给药方法,取得了一定的效果,唯其吸收作用没有规律且不可靠,因此即没能应用于临床,也不适用于实验。由于直肠相对来说缺乏消化酶,所以胰岛素直肠给药的蛋白降解作用,至少在一个短时间内不会发生。作者早先的实验表明:给予患者无表面活性剂的直肠用CZI胰岛素,当其剂量为每公斤体重10单位时,患者的葡萄糖和胰岛素水平都未发生明显的变化。因此,作者在本研究中,着重探 The way insulin is administered by the gastrointestinal route has been endeavored several times because of its potential clinical value. At that time, the oral administration method, and achieved some results, only the absorption of irregular and unreliable, and therefore can not be applied to clinical, nor is it suitable for the experiment. Due to the relative lack of digestive enzymes in the rectum, proteolytic degradation of insulin rectally does not occur for at least a short period of time. The authors earlier experiments showed that patients given no surfactant CZI insulin rectal, when the dose of 10 units per kilogram of body weight, the patient’s glucose and insulin levels did not change significantly. Therefore, the author focuses on this research