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本文研究了对一株金葡菌的体外抗菌活性相同、药代动力学基本相似而蛋白结合率明显不同的异噁唑组青霉素的蛋白结合率对体内抗菌活性的影响。作者分别以琼脂平皿法和微量肉汤双倍稀释法测定了上述抗生素对金葡菌Smith的最低抑菌浓度(MIC);以超滤法测定了抗生
In this paper, the antibacterial activity of Staphylococcus aureus in vitro with the same antibacterial activity, similar pharmacokinetics and different protein binding rates were investigated. The authors determined the minimum inhibitory concentration (MIC) of the antibiotics against S.aureus Smith by agar plate method and double broth microdilution method. The antibacterial activity