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检测了麦迪霉素和氨茶碱联合应用后9例慢性阻塞性肺部疾病患者的茶碱血药浓度,并以单用氨茶碱组做对照。结果表明:实险组血药浓度为14.12+2.28μg/ml,与对照组10.36±1.15μg/ml相比,有非常显著性差异(P<0.01);CI为0.0143+0.0034L/kg·h与对照组0.0210±0.0033L/kg·h相比,亦有非常显著差异;K值为0.0506±0.0095h,与对照组0.0674±0.0080h相比,亦有显著差异(P<0.01);Vd为0.2021±0.0615L/kg,比对照组0.2158±0.0286L/kg略低,但统计学处理无意义(P>0.05)。
The plasma concentration of theophylline in 9 patients with chronic obstructive pulmonary disease after combination therapy with methimycin and aminophylline was measured and compared with the aminophylline group alone. The results showed that: the blood concentration of actual insurance group was 14.12+2.28μg/ml, compared with the control group of 10.36±1.15μg/ml, there was a very significant difference (P<0.01); CI was 0.0143+0.0034L/kg·h Compared with the control group (0.0210±0.0033L/kg·h), there was also a significant difference; the K value was 0.0506±0.0095h, which was significantly different from the control group (0.0674±0.0080h) (P<0.01); Vd was 0.2021±0.0615L/kg, slightly lower than the control group 0.2158±0.0286L/kg, but statistically significant (P>0.05).