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目的观察改良VAD方案治疗多发性骨髓瘤(MM)的疗效。方法12例MM均为确诊病例,改良VAD方案为:第1～4天,长春新碱0.5mg/d加入0.9%生理盐水500ml中持续静脉滴注24h;第1～4天,阿霉素10mg/d加入0.9%生理盐水500ml中持续静脉滴注24h;第1～4天,地塞米松20mg/d加入0.9%生理盐水250ml中静脉滴注,第9～12、17～20天,地塞米松20mg,口服,1次/d。结果近期疗效12例患者中CR者3例(其中1例复发者),PR者6例(其中2例复发者),NR者3例(其中1例复发者),总有效率为75.0%。结论VAD方案治疗MM疗效确切,特别适宜基层医院和有肾功能损害及高钙血症的MM患者。
Objective To observe the curative effect of modified VAD regimen on multiple myeloma (MM). Methods 12 cases of MM were confirmed cases, the modified VAD program is: 1 to 4 days, vincristine 0.5mg / d 0.9% saline 500ml sustained intravenous infusion of 24h; 1 to 4 days, doxorubicin 10mg / d by adding 0.9% saline 500ml continuous intravenous infusion of 24h; 1 to 4 days, dexamethasone 20mg / d 0.9% saline 250ml intravenous infusion, the first 9 to 12,17 to 20 days, Misong 20mg, orally, 1 time / d. Results Among the 12 patients, 3 were CR, 1 was recurrent, 6 were PR, 2 were recurrent, 3 were NR, and 1 was recurrent. The total effective rate was 75.0%. Conclusion VAD regimen is effective in treating MM, especially suitable for primary hospital and MM patients with renal dysfunction and hypercalcemia.