N-烷基化反应是合成精细化工中间体的一种重要工艺,其合成方法很多,所得产品可应用于诸多领域。其中,以卤代烷烃、烷基醇、羧酸酯、磺酸酯作为烷基化试剂的取代N-烷基化反应是非常有用的反应类型,也是近期专利申请的热点课题之一。本文对取代型N-烷基化反应专利技术进行了概述。 N-alkylation reaction is an important process for the synthesis of fine chemical intermediates. There are many synthetic methods and the obtained products can be applied in many fields. Among them, the substituted N-alkylation reaction using alkyl halides, alkyl alcohols, carboxylic acid esters and sulfonic acid esters as alkylating agents is a very useful reaction type and is also one of the hot topics in recent patent applications. This article gives an overview of the patented technology for substituted N-alkylation.