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目的:研究下呼吸道标本分离的绿脓假单胞菌经环丙沙星(CPLX)次抑菌浓度(1/2MIC)诱导后对诺氟沙星(NFLX)等喹诺酮类药物以及非同类抗菌药物是否交叉耐药,为临床合理用药提供依据。方法:用1/2MIC CPLX诱导绿脓杆菌9d后,测定其对各抗菌药物的敏感性。结果:诱导后绿脓杆菌对CPLX纸片法的平均抑菌直径比诱导前小11mm,对于IMP和AMK纸片法,诱导前后的平均抑菌环直径未见变化。诱导后绿脓杆菌对CPLX、NFLX、PFLX和FLOX的MIC值分别是诱导前的4-16、4-16、4-16和4-32倍。结论:临床应用CPLX治疗绿脓杆菌感染时应注意剂量和疗程,避免因药物达不到有效的治疗浓度而导致治疗失败和耐药菌株的产生。
Objective: To investigate the effect of quinolones of norfloxacin (NFLX) and other non-same antibacterial drugs induced by Pseudomonas aeruginosa isolated from the lower respiratory tract after induced by the secondary inhibitory concentration (1 / 2MIC) of ciprofloxacin Whether cross-resistance, provide the basis for clinical rational drug use. Methods: After induced by Pseudomonas aeruginosa with 1 / 2MIC CPLX for 9 days, the sensitivity to each antibiotic was determined. Results: The average bacteriostatic diameter of Pseudomonas aeruginosa against CPLX disc was 11mm smaller than that before induction, and no change was observed for the average diameter of bacteriostasis before and after induced by IMP and AMK disc method. The MICs of Pseudomonas aeruginosa to CPLX, NFLX, PFLX and FLOX after induction were 4-16, 4-16, 4-16 and 4-32 times respectively before induction. Conclusion: CPLX should pay attention to dose and duration of treatment when treating CPN. It can avoid the failure of treatment and the emergence of drug-resistant strains due to the lack of effective treatment concentration.