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目的:研究豆腐果苷对慢性应激抑郁小鼠行为学的影响。方法:连续28d给予小鼠慢性不可预见性的刺激与孤养,建立小鼠抑郁模型,同时给予豆腐果苷(40、20、10mg/kg,i.g.)或盐酸氟西汀(2.6mg/kg,i.g.),采用敞箱试验、蔗糖饮水实验及情绪性行为评分等观察豆腐果苷的抗抑郁行为效应。结果:豆腐果苷可逆转慢性应激小鼠自发活动减少,糖水偏爱度降低,情绪性行为评分及体重的降低。结论:豆腐果苷对慢性应激小鼠具有抗抑郁作用。
Objective: To study the effect of tofu pectin on behavior of chronic stress depression mice. METHODS: Chronic unpredictable stimulation and isolation were given to mice for 28 consecutive days. Depression models were established in mice. At the same time tofuoside (40, 20, 10 mg / kg, ig) or fluoxetine hydrochloride (2.6 mg / kg, ig), using open-box test, sucrose drinking water test and emotional behavior score tofu glycosides observed antidepressant effect. Results: Tofuoside can reverse spontaneous activity of mice with chronic stress, reduce the degree of preference for sugar, emotional behavior score and weight loss. Conclusion: tofuin has antidepressant effects on chronic stress mice.