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慢性肾功能衰竭时常出现贫血与红细胞形态异常,特别在疾病的晚期多同时合并溶血。多年来上述异常引起了临床对尿毒症患者红细胞研究的兴趣。鉴于红细胞与白细胞在代谢紊乱方面各有异同之处,本文着重对上述两种细胞加以比较和讨论。〔红细胞〕尿毒症时红细胞的渗透脆性及自溶均中等度增加,但单纯出现此种异常并不能排除红细胞的先天缺陷。已证明尿毒症时除(Na~+ + K~+)-三磷酸腺苷酶与转酮酶外尚有多种红细胞酶的活性增加,透析后上述酶活性降低,然后趋于正常。关于活性降低的原因不明。葡萄糖消耗增加可产生乳酸盐。早期的
Chronic renal failure often appear anemia and abnormal erythrocyte morphology, especially in the advanced stage of the disease at the same time combined hemolysis. Over the years, these abnormalities have aroused clinical interest in erythrocyte research in uremic patients. In view of the similarities and differences between erythrocytes and leukocytes in metabolic disorders, this article focuses on the comparison and discussion of these two kinds of cells. Erythrocyte uremia, red blood cell infiltration fragility and autolysis were moderate increase, but simply such anomalies can not rule out the inherent defects of red blood cells. Uremia has been demonstrated in addition to (Na ~ + + K ~ +) - ATPase and transketolase outside a variety of red blood cell enzyme activity increased dialysis after the above enzyme activity decreased, and then tends to be normal. The reason for the decrease in activity is unknown. Increased glucose consumption produces lactate. Early