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目的:应用山莨菪碱对新生儿缺氧缺血性脑病的早期干预。方法:选自我科1997年1月～2006年9月收治的新生儿缺氧缺血性脑病患儿61例,随机分为两组,对照组30例,采用常规方法治疗;治疗组31例,在常规治疗的基础上,早期应用山莨菪碱。结果:治疗组与对照组在临床症状改善、体征恢复时间、住院天数、治愈率上相比具有显著性差异(P<0.05),治疗组明显优于对照组。结论:山莨菪碱在新生儿缺氧缺血性脑病中早期应用疗效显著。
OBJECTIVE: To investigate the early intervention of anisodamine in neonatal hypoxic-ischemic encephalopathy. Methods: Totally 61 children with neonatal hypoxic-ischemic encephalopathy were selected from our department from January 1997 to September 2006. They were randomly divided into two groups, control group (n = 30) and treatment group (n = 31) On the basis of conventional treatment, early application of anisodamine. Results: There were significant differences between the treatment group and the control group in clinical symptoms, signs recovery time, days of hospitalization and cure rate (P <0.05). The treatment group was significantly better than the control group. Conclusion: Anisodamine is effective in the early stage of neonatal hypoxic-ischemic encephalopathy.