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背景与目的:远端效应是肿瘤的局部治疗引起的远处抗肿瘤作用。本研究探索溶瘤腺病毒H101局部注射结合局部加热治疗诱发远端抗瘤效应的可行性。方法:放化疗失败或拒绝放化疗并有转移病灶的5例肿瘤患者(2例鼻咽癌,1例肺癌,1例骨旁质肉瘤和1例膀胱癌),以H101(5×1011～15×1011VP)瘤内注射联合60min42℃局部热疗进行治疗。结果:2例患者注射灶、非注射灶肿瘤完全消退而长期生存,3例患者也观察到非注射病灶有不同程度缓解后死亡,生存期分别为29、15、13个月。结论:H101瘤内注射联合加热治疗能诱发一定的远端抗瘤效应。
Background and Objective: Distal effects are distant anti-tumor effects caused by local treatment of tumors. This study explored the feasibility of local injection of oncolytic adenovirus H101 combined with local heating treatment induced distal anti-tumor effect. Methods: Five patients (2 NPC, 1 lung cancer, 1 parathyroid sarcoma and 1 bladder cancer) who failed or refused chemoradiotherapy and chemotherapy and had metastatic disease were treated with H101 (5 × 1011-15 × 1011VP) intratumoral injection combined 60min42 ℃ local hyperthermia for treatment. Results: In 2 patients, non-injecting tumor completely subsided and survived for a long time. Non-injected lesions were also observed in 3 patients with different degrees of remission after death. The survival time was 29, 15 and 13 months respectively. Conclusion: H101 intrathecal injection combined with heating treatment can induce certain distal anti-tumor effect.