论文部分内容阅读
目的:探讨血铅含量对学龄儿童耳蜗外毛细胞影响的相关性。方法:对云南省某铅锌矿区和邻近城区256例6~7岁儿童行血铅含量测定及耳声发射[瞬态耳声发射(TEOAE)及畸变产物耳声发射(DPOAE)]检测。结果:城区和矿区学龄儿童的血铅负荷水平差异有统计学意义(P<0.01);城区和矿区学龄儿童DPOAE的所有频率的平均信噪比(S/N)幅值与血铅含量均呈负相关性(均P<0.01);城区和矿区学龄儿童二者的血铅相关系数差异有统计学意义(P<0.01)。结论:矿区儿童铅负荷明显高于城区。人体铅暴露水平达高铅血症时,S/N幅值降低,估计随时间延长可能对耳蜗外毛细胞功能产生一定影响,影响程度可随血铅负荷加重而增高。
Objective: To investigate the correlation between blood lead levels and cochlear outer hair cells in school-age children. Methods: Blood lead levels and otoacoustic emissions (TEOAE) and distortion product otoacoustic emissions (DPOAE) were measured in 256 children aged 6-7 years in a Pb - Zn mining area and nearby urban areas in Yunnan Province. Results: There was a significant difference in blood lead levels among school-age children in urban areas and mining areas (P <0.01). The average signal-to-noise ratio (S / N) (P <0.01). There was significant difference in the blood lead correlation coefficient between the two groups (P <0.01). Conclusion: The lead load of children in mining area is obviously higher than that in urban area. When lead exposure to human lead is elevated, the S / N amplitude decreases. It is estimated that prolonged exposure may have some effect on the function of the outer hair cells of the cochlea, and the degree of influence may be increased with the increase of blood lead load.