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血管紧张素Ⅱ(AngⅡ)通过各种信号通路介导对缺血后血管再生的促进作用。但关于AngⅡ的两种受体亚型作用尚有争议。目前有关血管紧张素转换酶抑制剂(ACEI)在缺血性血管再生中的作用得出了促进和抑制血管形成两种结论。因此,ACEI在血管再生中的地位仍存在争议。
Angiotensin Ⅱ (AngⅡ) mediates the promotion of angiogenesis after ischemia by a variety of signaling pathways. However, the role of the two receptor subtypes Ang Ⅱ is controversial. At present, there are two conclusions about the role of angiotensin converting enzyme inhibitor (ACEI) in ischemic vascular revascularization to promote and inhibit angiogenesis. Therefore, ACEI in the role of angiogenesis is still controversial.