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沙利度胺最初用于治疗妊娠呕吐，因致畸事件而一度在临床禁用。基础研究业已证实沙利度胺有抗血管生成、免疫调剂及抗炎作用，因此推测其具有抗肿瘤潜能，该潜能在多发性骨髓瘤治疗中得以充分体现。沙利度胺治疗实体瘤目前尚处于探索阶段，现有文献多为病例报告、Ⅰ期和Ⅱ期临床研究，且疗效报道不一致，有待大样本的随机对照临床试验加以进一步证实。此外，沙利度胺对缓解癌症厌食恶病质综合征和化疗引起的胃肠道反应可能有一定价值。“,”Thalidomide originally was used for the treatment of vomiting of pregnancy, which was once forbidden in the clini?cal for teratogenic events. Basic researches have confirmed that thalidomide has the effect of anti?angiogenesis, immune adjustment and anti?inflammatory. Therefore, it is postulated that it has antitumor potential, as evident by the treatment of multiple myeloma. The treat?ment of solid tumors by thalidomide is still in the exploration stage. The existing literatures are focusing on case reports and phase Ⅰand Ⅱ clinical study with inconsistent curative effect, needing to be further confirmed by large?sample randomized controlled clinical trials. In addition, thalidomide may have a certain value to relieve the gastrointestinal reaction caused by chemotherapy and cancer ano?rexia cachexia syndrome.