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目的评价血清学肿瘤标记物对胰腺癌诊断和随访的价值。方法对８５例胰腺癌病人和２０例慢性胰腺炎病人进行血清学肿瘤标记物检测，并利用其对１５例可切除胰腺癌病人进行随访。结果４种肿瘤标记物中以ＣＡ１９９敏感性和特异性最好，分别为７４．１１％和９０％，联合检测可提高其敏感性，达８９．４１％。胰腺癌切除术后６０％的病人肿瘤标记物降至正常，随访中再次升高表明有肿瘤复发或转移。结论肿瘤标记物联合检测有助于胰腺癌早期诊断，并可用于评价治疗效果、监测肿瘤复发和转移。
Objective To evaluate the value of serological tumor markers in the diagnosis and follow-up of pancreatic cancer. Methods Serum tumor markers were detected in 85 patients with pancreatic cancer and 20 patients with chronic pancreatitis, and 15 patients with resectable pancreatic cancer were followed up. Results The sensitivity and specificity of CA199 in the four tumor markers were the best, which were 74.11% and 90%, respectively. Combined detection could increase the sensitivity, reaching 89.41%. In 60% of patients after pancreatic cancer resection, the tumor markers were reduced to normal, and increased again during follow-up indicates tumor recurrence or metastasis. Conclusion Combined detection of tumor markers is helpful for the early diagnosis of pancreatic cancer and can be used to evaluate the efficacy of treatment and monitor tumor recurrence and metastasis.