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目的探讨肾上腺外副神经节瘤临床及病理学特点、良恶性判断及鉴别诊断。方法对15例肾上腺外副神经节瘤病例的临床表现、组织形态学特征及免疫组化特点进行分析。结果肾上腺外副神经节瘤15例,男性4例、女性11例,年龄34~67岁,平均年龄54.9岁。肿瘤位于腹膜后6例,头颈部6例,纵隔、胆囊、腰椎管内各1例。有功能的3例,无功能的12例;组织学上肿瘤主要由主细胞和支持细胞两种细胞组成,免疫组化:肿瘤细胞Cg A、Syn、NSE、vimentin及S-100均(+),CK、EMA(-)。结论肾上腺外副神经节瘤的诊断依据组织形态学特点与免疫组化特征性表达。
Objective To investigate the clinical and pathological characteristics of adrenal paraganglioma, benign and malignant judgment and differential diagnosis. Methods The clinical manifestations, histomorphological features and immunohistochemical features of 15 cases of adrenal paraganglioma were analyzed. Results Adrenal gland paraganglioma in 15 cases, 4 males and 11 females, aged 34 to 67 years, with an average age of 54.9 years. The tumor was located in the retroperitoneum in 6 cases, head and neck in 6 cases, mediastinal, gallbladder, lumbar spinal canal in 1 case. There were 3 cases with function and 12 cases with no function. Histologically, the tumors mainly consisted of two main cells: the main cells and the supporting cells. Immunohistochemistry showed that the tumor cells were positive for Cg A, Syn, NSE, vimentin and S-100 , CK, EMA (-). Conclusion The diagnosis of adrenal paraganglioma is based on histomorphological features and immunohistochemical features.