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[目的]探讨肠外营养支持应用在极低出生体重儿中对消化功能和肝脏功能的影响及临床价值探讨。[方法]将我院治疗的极低出生体重儿采用随机数字法分为观察组和对照组,每组各68例,对照组给予延迟微量胃肠外营养支持,观察组给予早期胃肠外营养支持,对比2组患儿消化功能和肝脏功能变化情况。[结果]观察组患儿体重增加(27.86±5.49)g/d,住院时间(12.53±1.32)d,转全量胃肠道喂养时间(8.31±1.13)d,宫外生长发育迟缓率4.41%;对照组患儿体重增加(22.16±1.84)g/d,住院时间(18.69±2.79)d,转全量胃肠道喂养时间(13.25±2.85)d,宫外生长发育迟缓率16.18%,组间对比差异有统计学意义。观察组患儿出生后7d氨基酸(3.97±1.93)g·kg~(-1)·d~(-1),白蛋白(35.49±3.65)g/L,前白蛋白(99.69±13.54)mg/L;对照组患儿出生后7d氨基酸(2.44±1.01)g·kg~(-1)·d~(-1),白蛋白(32.04±2.38)g/L,前白蛋白(90.04±8.72)mg/L,组间对比差异有统计学意义(P<0.05)。观察组出生后7dTBIL(12.13±2.35)mg/dl,IBIL(9.13±1.24)mg/dl,DBIL(1.50±0.53)mg/dl;对照组出生后7dTBIL(14.66±4.31)mg/dl,IBIL(11.87±2.89)mg/dl,DBIL(1.54±0.55)mg/dl;其中TBIL和IBIL组间对比差异有统计学意义。[结论]早期胃肠外营养支持应用在极低出生体重儿中能够改善患儿营养状况,减轻患儿肝脏损伤程度,缩短治疗时间,值得在临床上推广应用。
[Objective] To investigate the effect and clinical value of parenteral nutrition support on digestive function and liver function in very low birth weight infants. [Methods] The very low birth weight children treated in our hospital were divided into observation group and control group by random number method, 68 cases in each group. The control group was given delayed parenteral nutrition support. The observation group was given early parenteral nutrition Support, compared with two groups of children with digestive function and liver function changes. [Results] The body weight of the observation group was (27.86 ± 5.49) g / d, the length of hospital stay was (12.53 ± 1.32) d, the time of full gastrointestinal feeding was (8.31 ± 1.13) d and the rate of extrauterine growth retardation was 4.41% The body weight of the control group was (22.16 ± 1.84) g / d, the length of hospital stay was (18.69 ± 2.79) d, the time of complete gastrointestinal feeding was (13.25 ± 2.85) days and the rate of extrauterine growth retardation was 16.18% The difference was statistically significant. The levels of amino acids (3.97 ± 1.93) g · kg -1 · d -1, albumin (35.49 ± 3.65) g / L, prealbumin (99.69 ± 13.54) mg / L and 2.47 ± 1.01 g · kg -1 · d -1, albumin (32.04 ± 2.38) g / L, prealbumin (90.04 ± 8.72) mg / L, the difference between the two groups was statistically significant (P <0.05). In the control group, the levels of TBIL (12.66 ± 4.31) mg / dL, IBIL (9.13 ± 1.24) mg / dl and DBIL (1.50 ± 0.53) mg / 11.87 ± 2.89) mg / dl and DBIL (1.54 ± 0.55) mg / dl, respectively. The difference between TBIL and IBIL was statistically significant. [Conclusion] The application of early parenteral nutrition support in children with very low birth weight can improve the nutritional status of children, reduce the degree of liver damage in children and shorten the treatment time, which is worth popularizing in clinic.