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目的观察肝素联合小剂量尿激酶治疗冠心病不稳定型心绞痛的临床效果。方法选取医院收治的冠心病不稳定型心绞痛患者40例,随机分为观察组和对照组,每组20例。对照组采用单纯常规治疗,观察组在常规治疗基础上采用肝素联合小剂量尿激酶治疗,并对2组患者疾病的治疗3 d前后比较和用药前后胸痛发作及心肌缺血情况、血流变化情况进行观察比较。结果用药14 d后根据患者症状及相关辅助检查指标,观察组患者临床总有效率为90.0%,高于对照组的60.0%(P<0.05)。2组患者用药后均能有效缓解胸痛发作及心肌缺血改善情况均有改善,且观察组效果大于对照组,差异有统计学意义(P均<0.05)。结论肝素联合小剂量尿激酶能安全有效治疗冠心病不稳定型心绞痛,各项指标及症状恢复良好,值得临床推广应用。
Objective To observe the clinical effect of heparin combined with low-dose urokinase in the treatment of unstable angina pectoris. Methods Forty patients with unstable angina pectoris who were admitted to hospital were randomly divided into observation group and control group, with 20 cases in each group. The control group was treated with simple routine therapy. The observation group was treated with heparin combined with low-dose urokinase on the basis of routine treatment. The changes of blood flow before and after treatment for 3 days in both groups were compared before and after treatment with chest pain and myocardial ischemia. Observe and compare. Results The total clinical effective rate was 90.0% in the observation group according to the symptoms of patients and the related auxiliary examination indexes after 14 days of treatment, which was higher than 60.0% of the control group (P <0.05). Both groups were able to effectively relieve the onset of chest pain and myocardial ischemia after treatment, and the effect of the observation group was greater than that of the control group (P <0.05). Conclusion Heparin combined with low-dose urokinase can be used safely and effectively in the treatment of unstable angina pectoris. The indexes and symptoms recovered well and is worthy of clinical application.