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目的评价稳心颗粒与比索洛尔联合治疗冠心病频发室性早搏的临床疗效及安全性。方法将冠心病合并室性早搏患者183例随机分为3组:比索洛尔组(A组)60例,稳心颗粒组(B组)60例,稳心颗粒联合比索洛尔(C组)63例,观察治疗前后患者临床症状和心律失常改善情况及不良反应。结果治疗前后动态心电图疗效C组与B组和A组在显效率、有效率、无效率及总有效率方面比较差异有统计学意义(P<0.05);治疗后C组患者24h早搏总数显著低于B组和A组,分别为152±107、698±203和758±234,P<0.01;三组患者治疗前后临床症状均有明显改善,C组总有效率显著高于A、B组(P<0.05),C组无效率显著低于A、B组(P<0.01);三组患者均未发生严重不良反应。结论稳心颗粒治疗冠心病频发室性早搏的临床疗效与比索洛尔相当,两者联合应用与单独使用相比,前者可更好地控制室性早搏的发生及明显缓解临床症状。
Objective To evaluate the clinical efficacy and safety of Wenxin Granules and Bisoprolol in the treatment of frequent ventricular premature beats with coronary heart disease. Methods 183 patients with coronary heart disease and ventricular premature beats were randomly divided into three groups: 60 cases in the group of Bisoprolol (group A), 60 cases in the group of Wenxin granules (group B), and 60 cases in the group of wenxin granules combined with bisoprolol (group C) 63 cases were observed before and after treatment of patients with clinical symptoms and improvement of arrhythmia and adverse reactions. Results Before and after treatment, the effect of Holter in group C was significantly different from group B and group A in terms of apparent efficiency, effective rate, inefficiency and total effective rate (P <0.05). After treatment, the total number of 24h premature beats in group C was significantly lower In group B and group A, they were 152 ± 107, 698 ± 203 and 758 ± 234, respectively, P <0.01. The clinical symptoms of the three groups were significantly improved before and after treatment. The total effective rate in group C was significantly higher than that in group A and B P <0.05), and the inefficacy of group C was significantly lower than that of group A and B (P <0.01). No serious adverse reactions occurred in all three groups. Conclusion Wenxin Granule has the same curative effect as bisoprolol in the treatment of frequent premature ventricular contractions in patients with coronary heart disease. The combination of these two drugs can better control the occurrence of ventricular premature beats and relieve the clinical symptoms significantly.