论文部分内容阅读
以聚肽、壳聚糖为原料,制备复合纳米粒子,采用透射电镜、动态激光散射仪及Zeta电位分析仪、荧光光谱仪对制备成的聚肽-壳聚糖复合体系纳米粒子的形貌、粒径、Zeta电位及临界胶束浓度等自组装行为进行表征,结果表明:聚肽-壳聚糖复合体系纳米粒子是具有壳-核结构的球型粒子;纳米粒子平均粒径为240nm,粒径分布较均匀,稳定性较好;复合体系中聚肽的临界胶束浓度为4.55×10~(-4)mg/mL.“,”Biocompatible amphiphilic polypeptide-chitosan was used to prepare nanoparticles by self-assembly and ion gel methods. The self-assembly behavior of the polypeptides-chitosan composite nanoparticles such as morphology, particle size ,Zeta potential and critical micelle concentration (CMC) were studied by transmission electron microscopy, dynamic light scattering, Zeta potential analyzer and fluorescence spectroscopy . The results showed that the morphology of nanoparticles was spherical with the shell-core structure,the size of nanoparticles was 240nm,and its distribution was homogeneous. The particles had good stability. The CMC of polypeptides in composite system was 4.55 ×10~(-4) mg/mL.