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目的探讨血液病患者产生血小板抗体的影响因素及血小板抗体阳性患者经血小板交叉配型后的输注效果。方法用全自动血型仪,采用固相抗体检测法进行血小板抗体筛选及交叉配型,对血小板输注有效率进行统计学分析。结果血小板相关抗体的产生与妊娠史、输血史相关,对产生抗体的患者进行血小板交叉配型后,24h CCI>4.5者为86.7%。结论对于血小板抗体阳性的患者,在保证同型输注的基础上进行血小板交叉配型可以极大的提高血小板输注效率,减少血小板输注无效症的发生。
Objective To investigate the influencing factors of platelet antibodies in patients with hematological diseases and the effect of transfusion after platelet crossmatch with platelet antibody positive patients. Methods The automatic blood type analyzer was used to detect platelet antibody and crossmatch with solid-phase antibody test, and the efficiency of platelet transfusion was statistically analyzed. Results The production of platelet-associated antibodies was correlated with the history of pregnancy and blood transfusion. After 24h platelet cross matching, the CCI of 4.5 patients was 86.7%. Conclusion For patients with positive platelet antibodies, platelet cross-matching based on the same type of infusion can greatly improve platelet transfusion efficiency and reduce the incidence of platelet transfusion ineffectiveness.