目的分析原发性闭经患者的染色体核型与病因。方法分析122例原发性闭经患者外周血染色体核型。结果 122例原发闭经患者中检出40例异常核型,占受检者32.79%,其中性染色体异常36例,占异常核型的90%,常染色体异常4例,占异常核型的10%。结论染色体异常是导致原发性闭经的重要原因之一。 Objective To analyze the karyotype and etiology of primary amenorrhea patients. Methods 122 cases of primary amenorrhea patients with peripheral blood chromosome karyotype. Results A total of 122 cases of primary amenorrhea patients were detected in 40 cases of abnormal karyotype, accounting for 32.79% of the subjects, including 36 cases of chromosomal abnormalities, accounting for 90% of anomalous karyotype, autosomal abnormalities in 4 cases, accounting for 10 cases of abnormal karyotype %. Conclusion Chromosomal abnormalities are one of the important causes of primary amenorrhea.