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本文介绍了人体在接触环境致癌物如N-亚硝基化合物、黄曲霉毒素、乙烯氧化物、苯并芘及其它DNA损伤剂后,能在细胞和体液中测出致癌物(或其代谢物)与DNA或血红蛋白共价结合的加合物。同时还介绍了免疫学方法、化学分析法和~(32)P后标记法在检测加合物可的应用。并指出DNA和血红蛋白加合物可以作为人体接触致癌物的标志。
This article describes the detection of carcinogens (or their metabolites) in cells and body fluids after exposure to environmental carcinogens such as N-nitroso compounds, aflatoxins, ethylene oxide, benzopyrene and other DNA damaging agents ) Adducts covalently bound to DNA or hemoglobin. At the same time, immunological methods, chemical analysis and ~ (32) P labeling method were introduced to detect the adduct. And pointed out that DNA and hemoglobin adducts can be used as a sign of human exposure to carcinogens.