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促分裂原活化蛋白激酶途径是细胞生长和分化的重要环节。最近发现了一种新的选择性的上游激酶 MEK的抑制剂 PD1 84352。 PD1 84352具有口服活性 ,能抑制小鼠结肠癌中 80 %的肿瘤生长。结果表明 MEK抑制剂代表了一种新的非细胞毒的结肠癌治疗方法。
Mitogen-activated protein kinase pathway is an important part of cell growth and differentiation. Recently a new and selective inhibitor of upstream kinase MEK PD1 84352 was found. PD1 84352 is orally active and inhibits 80% of tumor growth in mouse colon cancer. The results show that MEK inhibitors represent a new non-cytotoxic treatment of colon cancer.