虽然人们早就认识到人体对职业毒物的反应有很大差别,而且 Garnow(1976)即以此为根据,提出在制订卫生标准时,“剂量-反应”关系比“剂量-效应”关系更应受重视;但长期以来,由于未能解决方法学问题,因而个体敏感性问题只能停留在描述性研究上。70年代,提出了高危人群的概念, Although it has long been recognized that there is a wide range of human reactions to occupational toxicants, and based on this, Garnow (1976) suggests that the “dose-response” relationship should be more relevant than the “dose-effect” relationship when formulating health standards However, for a long time, due to the failure to solve the problem of methodological study, the problem of individual sensitivity can only stay in descriptive research. In the 70s, put forward the concept of high-risk groups,