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目的探讨新诊断2型糖尿病(DM)患者应用胰岛素联合文迪雅治疗的效果。方法采用开放随机平行对照方法将82例新诊断2型DM患者分为两组。单用组42例,单用胰岛素治疗;联用组26例,胰岛素加罗格列酮联合治疗。治疗前及治疗12周末做口服糖耐量(OGTT)试验及胰岛素释放试验,检测0、30、60、120、180min血糖(BG)、C肽(CP)水平等,根据结果计算△CP30/△BG30等。评估胰岛素治疗对新诊断2型DM患者胰岛β细胞功能的价值。结果两组均使FBG、2hPBG、HbA1c水平明显下降,且联用组显著优于单用组(P<0.01)。两组均可改善△CP30/△BG30;联用组△CP30/△BG30明显增加,显著优于单用组(P<0.05)。结论对于新诊断2型DM出现胰岛β细胞功能衰减的患者,早期应用胰岛素可明显降低血糖,减轻胰岛β细胞负荷,使胰岛β细胞功能得到部分改善,如果胰岛素与胰岛素增敏剂联合使用效果最佳。
Objective To investigate the effect of insulin combined with Avandia in patients newly diagnosed with type 2 diabetes mellitus (DM). Methods Eighty-two patients with newly diagnosed type 2 DM were divided into two groups by open randomized parallel control. In the treatment group, 42 patients were treated with insulin alone; 26 patients in combination group were treated with insulin plus rosiglitazone. The oral glucose tolerance (OGTT) test and insulin release test were performed before treatment and at the end of 12 weeks of treatment. The levels of blood glucose (BG) and C peptide (CP) at 0, 30, 60, 120 and 180min were measured. Wait. Assess the value of insulin therapy for pancreatic β-cell function in newly diagnosed type 2 DM patients. Results The levels of FBG, 2hPBG and HbA1c in both groups were significantly decreased, and the combined group was significantly better than the single group (P <0.01). Both groups improved △ CP30 / △ BG30; combined group △ CP30 / △ BG30 increased significantly, significantly better than the single use group (P <0.05). Conclusion In the newly diagnosed type 2 diabetic patients with decayed pancreatic β-cell function, early application of insulin can significantly lower blood glucose and reduce the load of pancreatic β-cells, so that the function of islet β cells is partially improved. If insulin and insulin sensitizer are used in combination, good.