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随着肺移植、体外循环以及肺外科中单侧肺循环阻断技术的广泛应用,肺缺血再灌注损伤(LIRI)对于术后肺功能的影响日益受到关注。术中因肺缺血而引起的肺组织坏死一直被认为是影响肺功能的最重要原因,然而近年的研究表明细胞凋亡尤其是肺泡Ⅱ型上皮细胞(ATⅡ)的凋亡也起重要作用,凋亡在肺缺血再灌注损伤中的机制成为研究热点。文中对该领域的最新进展进行综述。
With the extensive application of lung transplantation, cardiopulmonary bypass, and unilateral pulmonary circulation occlusion in lung surgery, the impact of lung ischemia-reperfusion injury (LIRI) on postoperative pulmonary function has drawn increasing attention. Intraoperative pulmonary necrosis caused by pulmonary ischemia has been considered the most important factor affecting lung function, however, recent studies have shown that apoptosis, especially apoptosis of alveolar type Ⅱ epithelial cells (AT Ⅱ) also plays an important role, Apoptosis in lung ischemia-reperfusion injury mechanism has become a research hotspot. The article reviews recent developments in this area.