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慢性阻塞性肺疾病(COPD)以气道、肺实质和肺血管的慢性炎症为特征,近年来发现他汀类药物除降脂作用外,还可改善COPD患者的症状及预后。血管紧张素Ⅱ受体拮抗剂,能抑制肺血管缺氧性收缩以及慢性缺氧时血管的重建。能防止COPD患者肺动脉高压的病程进展及肺功能的下降。两者合用有协调作用,不仅能缓解COPD患者的症状,还能延缓COPD的进程,降低死亡率。
Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation of the airways, lung parenchyma, and pulmonary vessels. In recent years, statins have been shown to improve symptoms and prognosis in patients with COPD, in addition to lipid-lowering effects. Angiotensin II receptor antagonists inhibit pulmonary vascular hypoxic contractions and vascular reconstruction during chronic hypoxia. Can prevent the progression of pulmonary hypertension in patients with COPD and pulmonary function decline. The combined effect of both can not only relieve the symptoms of COPD patients, but also delay the process of COPD and reduce the mortality rate.