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用放免法测定９８例中风病人的血浆内皮素（ＥＴ）含量在不同病情、病程时期的动态变化。结果发现ＩＴＡ与脑供血不足患者ＥＴ水平明显高于对照组（Ｐ＜０．０５）；脑梗塞患者急性期及恢复期ＥＴ水平均较对照组有显著差异（Ｐ＜０．０１），且梗塞范围越大ＥＴ水平增高越显著；ＳＡＨ病人发病后１周ＥＴ水平迅速上升高达数倍，４周后即降至原有水平。结果表明ＥＴ参与了中风的发生与发展，是引起缺血损伤和脑血管痉挛的重要因素。
The radioimmunoassay was used to determine the dynamic changes of plasma endothelin (ET) in 98 patients with stroke in different stages and duration of disease. The results showed that the level of ET in patients with ITA and cerebral insufficiency was significantly higher than that in the control group (P <0.05). The acute and convalescent ET levels in patients with cerebral infarction were significantly different from those in the control group (P <0.01) The larger the range, the more significant the ET level increased. The level of ET in the patients with SAH increased rapidly several times one week after the onset of SAH, and dropped to the original levels after 4 weeks. The results show that ET is involved in the occurrence and development of stroke and is an important factor that causes ischemic injury and cerebral vasospasm.