论文部分内容阅读
辅助性T细胞（Th）17是 CD4＋T 细胞的一类亚群，是由 Th0细胞在白细胞介素（IL）6和IL－23的刺激下分化而成的Th细胞。 Th17细胞分泌的细胞因子主要有IL－17和IL－22等。 Th17细胞对于自身免疫性疾病和机体防御反应有重要作用。近期的研究突出了在肾小球肾炎中 Th17细胞和IL－17介导肾组织损伤的证据。该文通过探究Th17细胞在自身免疫性疾病中的作用，研究其在肾炎相关疾病发生和发展过程中的重要作用，并从Th17细胞与实验性肾炎和人类肾炎分别阐述其在临床中的意义，为未来自身免疫性疾病的研究提供一个新的方向。“,”T helper(Th) 17 cells are a subset of CD4+T cells,which is differentiated from Th0 cells stimulated by interleukin ( IL)-6 and IL-23.The cytokines secreted by Th17 cells mainly include IL-17, IL-22,etc.Th17 cells play an important role in autoimmune diseases and body′s defense response.Recent studies have highlighted evidence of Th17 cell and IL-17 mediating renal tissue damage in glomerulonephri-tis.Here is to make a review of the Th17 cells in the autoimmune diseases are discussed in detail,and explore its important role in the occurrence and development of nephritis , the relationship between Th17 cells and experimental nephritis and human nephritis,and provide a new direction for the study of autoimmune diseases in the future.