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内界膜剥除术因能够有效地解除玻璃体视网膜界面的牵拉而在多种玻璃体视网膜疾病中得到应用,但其对巨大、难治性黄斑裂孔及高度近视性黄斑裂孔等棘手疾病的效果欠佳.同时,内界膜剥除本身及染色剂的使用均可导致黄斑发生结构和功能的改变.为了更好地保持黄斑结构的完整性,多种改良的内界膜剥除术,如翻转内界膜瓣、自体内界膜移植、保留中心凹的内界膜剥除术应运而生.研究显示这些新术式在治疗巨大黄斑裂孔、高度近视性黄斑裂孔以及难治性黄斑裂孔上表现出较好的解剖和功能疗效,且无明显的并发症,但仍需要更多大样本的长期随访研究来证实.本文就内界膜剥除术的改良方式及其在玻璃体视网膜中的应用情况进行综述.“,”Internal limiting membrane (ILM) peeling technique has been widely used in the treatment of a variety of vitreoretinal diseases for the advantage of releasing vitreomacular traction.However,this routine approach was less effective in refractory macular disorders.Meanwhile,the technique and the use of stains could lead to structural and functional changes of macular.Therefore,to better preserve macular structure,modified ILM peeling techniques including inverted ILM flap technique,autologous transplantation of ILM technique and the foveola nonpeeling ILM technique emerged.Recent researches had demonstrated favorable structural and functional outcomes of these techniques on giant macular hole,refractory macular hole and high myopic macular hole.However,more longterm follow-up studies with larger samples are needed to confirm the current results.In this paper,we reviewed the progress of modified ILM peeling technique in vitreoretinal diseases.