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目的 研究鼻咽癌血管内皮生长因子 ,C erbB2 ,p5 3的表达与鼻咽癌生存时间 ,转移之间的相关性和与其不同组织学类型的关系 ,探讨VEGF ,C erbB2 ,p5 3在预测判断鼻咽癌预后中的作用。方法 应用免疫组化S P法 ,检测 10 3例鼻咽癌的VEGF ,C erbB2 ,p5 3的表达特征。结果 发现在10 3例附有完整随访资料的鼻咽癌病例中 ,VEGF的表达与鼻咽癌患者的生存时间 ,转移有相关性 ,p5 3的表达与鼻咽癌病人的远处转移相关 ,检验均有显著性差异 (P <0 0 1,P <0 0 5 )。而VEGF ,C erbB2 ,p5 3表达与鼻咽癌各组织学类型无关 (P >0 0 5 )。同时C erbB2 表达与鼻咽癌患者生存时间和转移无关 (P >0 0 5 )。p5 3的表达与鼻咽癌患者生存时间无关。结论 VEGF在鼻咽癌活检组织中的高表达 ,说明该病例易转移 ,生存时间短 ,结合p5 3的检测可判断鼻咽癌的高危转移特性
Objective To investigate the relationship between the expression of vascular endothelial growth factor, C erbB2, p5 3 and the survival time and metastasis of nasopharyngeal carcinoma (NPC) and their relationship with different histological types, and to explore the correlation between VEGF, C erbB2 and p5 3 The role of nasopharyngeal carcinoma prognosis. Methods Immunohistochemical SP method was used to detect the expression of VEGF, C erbB2 and p5 3 in 103 cases of nasopharyngeal carcinoma. The results showed that in 103 NPC cases with complete follow-up data, the expression of VEGF was correlated with the survival time and metastasis of NPC patients. The expression of p5 3 was associated with the distant metastasis of NPC patients, The test showed significant difference (P <0.01, P <0.05). The expression of VEGF, C erbB2 and p5 3 had no correlation with the histological types of NPC (P> 0.05). Meanwhile, the expression of C erbB2 was not related to the survival time and metastasis of NPC patients (P> 0.05). p5 3 expression has nothing to do with the survival time of patients with nasopharyngeal carcinoma. Conclusion The high expression of VEGF in the biopsy tissues of nasopharyngeal carcinoma indicates that the cases are easy to metastasize and the survival time is short. Combined with the detection of p5 3, the high-risk metastasis characteristics of nasopharyngeal carcinoma can be judged