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目的:通过对右旋糖酐40葡萄糖注射液引起儿童药品不良反应(ADR)病例的分析,总结临床应用该药时的注意事项,为右旋糖酐40葡萄糖注射液的合理应用提供参考。方法:收集2013年我院应用右旋糖酐40葡萄糖注射液发生药品不良反应的患儿病例7例,应用Excel软件从用法用量、发生不良反应时间等方面进行总结和分析。结果:右旋糖酐40葡萄糖注射液的药品不良反应多发生在给药过程中或给药结束2 h内,严重药品不良反应更容易发生在第1次给药时。结论:临床上给予患儿右旋糖酐40葡萄糖注射液治疗,在第1次给药时应密切观察患儿症状、体征,并做好充分的不良反应防治措施准备,以防严重药品不良反应的发生;过敏体质者,建议做皮试后再用。
OBJECTIVE: To summarize the precautions of clinical application of this medicine by analyzing the cases of children’s adverse drug reaction (ADR) induced by dextran 40 glucose injection and to provide a reference for the rational application of dextran 40 glucose injection. Methods: Seven cases of children with adverse drug reactions using dextran 40 glucose injection in our hospital in 2013 were collected and analyzed by Excel software from the aspects of dosage, adverse reaction time and so on. Results: Adverse reactions to dextran 40 glucose injection occurred in the course of administration or within 2 h after the end of administration. Serious adverse drug reactions were more likely to occur at the first administration. Conclusion: The dextran 40 dextran injection in children should be treated clinically. Symptoms and signs in children should be observed closely during the first administration. Adequate adverse reaction preparation should be made to prevent serious adverse drug reactions. Allergies, it is recommended to do skin test before use.