心房利钠尿肽(atrial natriuretic peptide,ANP)又名心钠素,是1981年由De Bold等[1]首先从大鼠心房组织发现并提取,主要由心房细胞分泌的一类具有利尿、利钠、抑制肾素-血管紧张素-醛固酮系统,扩血管及降低血压等作用的多肽激素,对循环系统有多种生物学功能;充血性心力衰竭(con-gestive heart failure,CHF)时,作为心肌对房室张力、心衰病理演变及心肌重构作出反映的标志,血浆心钠素(PANP)含量可显著升高,因而在CHF的临床实践中具有重要价值[2～4]。 Atrial natriuretic peptide (atrial natriuretic peptide, atrial natriuretic peptide, also known as atrial natriuretic peptide, was first discovered in 1981 by De Bold et al [1] and extracted from atrial tissue, mainly by the atrial cells with a class of diuretic, Sodium, a peptide hormone that inhibits the renin-angiotensin-aldosterone system, vasodilators and blood pressure, has multiple biological functions on the circulatory system. In the con-gestive heart failure (CHF) Myocardium atrioventricular tension, pathological changes of heart failure and myocardial remodeling reflect the signs of plasma atrial natriuretic peptide (PANP) content can be significantly increased, and thus in the clinical practice of CHF has an important value [2-4].