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甲氰咪胺(Cimetidin)为一种组织胺—2(H_2)受体拮抗剂或H_2阻断剂,显著抑制壁细胞的基础或刺激性胃酸分泌,用以治疗酸性溃疡病。但其他细胞如T细胞也有H_2受体,故组织胺可能与细胞免疫调节有关。本文研究甲氰咪胺对活动性十二指肠溃疡患者体内细胞免疫的影响。确诊活动性十二指肠溃疡病人16名,8名口服甲氰咪胺(300毫克、日四次)与抗酸剂6周;对照病人接受安慰剂与抗酸剂。开始治疗前(0天)及治疗42天后,分别用结核菌素纯蛋白衍生物、念珠菌素、毛癣菌素、双链酶测定皮肤迟缓超敏反应。在注射后24与48小时分别测量红斑和硬结的长及横径。结果分;增强、减弱、未定、及无改变。结果治疗前及治疗后6周,双链酶皮试硬结在24及48小时,甲氰咪胺组均显著大于对照组(P<0.005)。
Cimetidin is a histamine-2 (H 2) receptor antagonist or H 2 blocker that significantly suppresses parietal cell basal or stimulatory gastric acid secretion for the treatment of acid ulcer disease. However, other cells such as T cells also have H 2 receptors, so histamine may be related to cellular immune regulation. This article studies the effects of mecalamine on cellular immunity in patients with active duodenal ulcer. Sixteen patients with active duodenal ulcer were diagnosed, eight were given mecamylamine (300 mg, day four) and antacids for 6 weeks. Control patients received placebo and antacids. Delayed hypersensitivity to the skin was measured before treatment (day 0) and after 42 days of treatment, respectively, with tuberculin pure protein derivatives, candida, veltins, and double-stranded enzymes. The length and transverse diameter of erythema and induration were measured at 24 and 48 hours after injection, respectively. Result points; increase, decrease, undetermined, and no change. Results Before treatment and 6 weeks after treatment, the histological stratification of double-stranded enzyme skin was significantly greater at 24 and 48 hours in the cidamerazine group than in the control group (P <0.005).