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目的探讨中青年症状性动脉粥样硬化颅内动脉狭窄(s ICAS)患者中低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-C/HDL-C)比值的变化及其在预后评估中的临床价值。方法以2012年1月到2013年12月收治的81例中青年s ICAS患者为研究对象,根据第4届全国脑血管病会议公布的诊断标准,并经头颅CT或MRI诊断,分为脑卒中组(41例)和非脑卒中组(40例),选取同期接受体检的健康者40例(对照组),对比分析3组入选者的LDL-C、HDL-C和LDL-C/HDL-C水平。结果脑卒中组41例,颅内动脉狭窄重度28例(68.29%),中度6例(14.63%),轻度7例(17.07%);非脑卒中组40例,颅内动脉狭窄重度7例(17.50%),中度6例(15.00%),轻度27例(67.50%),两组比较差异有统计学意义(P<0.01)。按对照组、非脑卒中组、脑卒中组的顺序,其LDL-C[(3.10±0.42)mmol/L、(3.39±0.84)mmol/L、(3.72±0.92)mmol/L]、LDL-C/HDL-C[2.23±1.06、2.80±1.24、3.61±1.28]依次升高(P均<0.05),HDL-C[(1.38±0.22)mmol/L、(1.19±0.42)mmol/L、(1.03±0.36)mmol/L]依次降低(P<0.05),差异有统计学意义。结论中青年s ICAS患者的LDL-C/HDL-C比值明显升高,可作为s ICAS疾病诊疗及预测预后的重要指标。
Objective To investigate the changes of low density lipoprotein cholesterol / high density lipoprotein cholesterol (LDL-C / HDL-C) ratio in patients with symptomatic atherosclerosis intracranial arterial stenosis (s ICAS) Clinical Value. Methods From January 2012 to December 2013, 81 cases of young and middle-aged patients with ICAS were enrolled in the study. According to the diagnostic criteria published by the 4th National Cerebrovascular Disease Conference and by head CT or MRI diagnosis, they were divided into stroke (N = 41) and non-stroke group (n = 40). Forty healthy subjects (control group) were enrolled in the study. The levels of LDL-C, HDL-C and LDL- C level. Results There were 41 cases of stroke group, 28 cases (68.29%) of severe intracranial stenosis, 6 cases (14.63%) moderate and 7 (17.07%) mild cases, 40 cases of non-stroke group and 7 cases of severe intracranial artery stenosis (17.50%), 6 moderate (15.00%) and 27 mild (67.50%). There was significant difference between the two groups (P <0.01). The levels of LDL-C [(3.10 ± 0.42) mmol / L, (3.39 ± 0.84) mmol / L, (3.72 ± 0.92) mmol / L] in the control, non-stroke and stroke groups, (1.38 ± 0.22) mmol / L, (1.19 ± 0.42) mmol / L, HDL-C [2.23 ± 1.06,2.80 ± 1.24,3.61 ± 1.28] (1.03 ± 0.36) mmol / L] (P <0.05), the difference was statistically significant. Conclusions The LDL-C / HDL-C ratio in young and middle-aged patients with ICAS is significantly increased, which can be used as an important index for the diagnosis and prognosis of ICAS.