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转铁蛋白受体(TrfR)免疫化学染色已被广泛应用于检测细胞增殖率,并认为对某些恶性肿瘤类型具有一定预后价值。Sato对101例原发性肺癌作OKT_9(抗转铁蛋白受体抗体)免疫组织化学染色发现,57例肺腺癌中11例(19％)呈阳性染色。为进一步观察TrfR表达作为肺腺癌预后指标之一,作者研究58例手术切除肺腺癌标本对OKT_9免疫组织化学反应性。作者从1987年4月至1988年8月间手术获得肿瘤标本随机选择58例原发性肺腺癌进行研究,其中Ⅰ期20例,Ⅱ期6例,Ⅲ_A期17例,Ⅲ_B期2例,Ⅳ期13例。肿瘤分化良好19例,中度
The transferrin receptor (TrfR) immunochemical staining has been widely used to detect cell proliferation rates, and it is considered to have certain prognostic value for certain types of malignant tumors. Sato’s immunohistochemical staining for OKT 9 (anti-transferrin receptor antibody) in 101 patients with primary lung cancer revealed positive staining in 11 out of 57 lung adenocarcinomas (19%). To further observe TrfR expression as one of the prognostic indicators of lung adenocarcinoma, the authors studied the immunohistochemical reactivity of OKT_9 in 58 surgically resected lung adenocarcinoma specimens. The authors randomly selected 58 cases of primary lung adenocarcinoma from surgical specimens obtained from April 1987 to August 1988, including 20 patients in stage I, 6 in stage II, 17 in stage III_A, and 2 in stage III_B. IV stage 13 cases. Good tumor differentiation in 19 cases, moderate