环状RNA(circular RNAs,circ RNAs)是一类新发现的内源性非编码RNA,是RNA领域的研究热点。circ RNAs呈闭合环状结构,具有结构稳定、高度保守以及组织和发育阶段特异表达等特征。circ RNAs参与多种生物学功能,除了mi RNA海绵吸附功能,更多新的功能正逐渐被发现,如调节基因转录和剪切以及翻译蛋白质等。目前已有大量研究表明,circ RNAs与疾病和发育等生理病理过程密切相关。本文重点对circ RNAs的生物学功能以及其在生殖、围产领域的研究进展进行综述。 Circular RNAs (circular RNAs) are a newly discovered class of endogenous non-coding RNAs and are the hotspots in RNA field. Circ RNAs are closed loop structure, with structural stability, highly conserved and specific expression of the stage of development and other characteristics. Circ RNAs are involved in a variety of biological functions. In addition to the mi RNA sponge adsorption function, more and more new functions are gradually being discovered, such as regulating gene transcription and cleavage and translation of proteins. A large number of studies have shown that circ RNAs are closely related to the physiological and pathological processes such as disease and development. This review focuses on the biological functions of circ RNAs and their progress in reproductive and perinatal studies.