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Purpose:.To determine the penetrability of riboflavin into the ceal stroma by iontophoresis and to compare the perme-ability effects of different solvents.
Methods:.Twenty rabbits were randomly divided into four groups:.a group that received 0.1% riboflavin-balanced salt solution (BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis,.a group that re-ceived 0.1% riboflavin-distilled water solution by iontophore-sis, and a control group that received classical riboflavin in-stillation after ceal de-epithelialization..The degree of yel-lowing of the de-epithelialized ceal stromal button from each rabbit was compared.
Results:.The yellow color scores for the ceal stromal but-tons in the three iontophoresis groups were compared with those of control group..Iontophoretic delivery of a 0.1% ri-boflavin-distilled water solution yielded similar yellow changes in the ceal stromal button when compared with classical ri-boflavin instillation after de-epithelialization..However,.the other two solvents did not sufficiently enhance the permeabili-ty of riboflavin.
Conclusion:.Riboflavin can effectively penetrate into the ceal stroma to saturation levels by iontophoresis..Using distilled water as the solvent can promote penetrability.. (Eye Science 2014; 29:30-35).
Methods:.Twenty rabbits were randomly divided into four groups:.a group that received 0.1% riboflavin-balanced salt solution (BSS) by iontophoresis, a group that received 0.1%riboflavin-saline solution by iontophoresis,.a group that re-ceived 0.1% riboflavin-distilled water solution by iontophore-sis, and a control group that received classical riboflavin in-stillation after ceal de-epithelialization..The degree of yel-lowing of the de-epithelialized ceal stromal button from each rabbit was compared.
Results:.The yellow color scores for the ceal stromal but-tons in the three iontophoresis groups were compared with those of control group..Iontophoretic delivery of a 0.1% ri-boflavin-distilled water solution yielded similar yellow changes in the ceal stromal button when compared with classical ri-boflavin instillation after de-epithelialization..However,.the other two solvents did not sufficiently enhance the permeabili-ty of riboflavin.
Conclusion:.Riboflavin can effectively penetrate into the ceal stroma to saturation levels by iontophoresis..Using distilled water as the solvent can promote penetrability.. (Eye Science 2014; 29:30-35).