脑出血是一种高发病率和高死亡率的疾病,出血后的一系列继发性反应可以造成的严重的神经功能损伤。近年来,研究发现多个microRNA在脑出血后异常表达,参与了出血后的氧化损伤、炎症、水肿以及神经细胞凋亡等多个病理生理过程,从而加重了脑出血后继发性脑损伤。本文综述了目前microRNAs在脑出血后病理生理机制中作用的相关研究。 Intracerebral hemorrhage is a disease with high morbidity and mortality, and serious neurological damage can be caused by a series of secondary reactions after hemorrhage. In recent years, it has been found that multiple microRNAs are abnormally expressed after intracerebral hemorrhage and are involved in multiple pathophysiological processes such as oxidative damage, inflammation, edema and neuronal apoptosis after hemorrhage, thus aggravating secondary brain injury after intracerebral hemorrhage. This review summarizes the current research on the role of microRNAs in the pathophysiology of intracerebral hemorrhage.