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在大鼠尾静脉注射6-18F-L-多巴(18F-DOPA)后5、30、60、90、120和150min时处死动物,测定大鼠体内各脏器中18F活度分布,换算至标准人体内分布,按MIRD法估算人体18F-DOPA内照射吸收剂量。估算结果表明,肾脏的内照射吸收剂量最高,为22.9pGy/Bq,脑的内照射吸收剂量为11.8pGy/Bq,其它脏器的内照射吸收剂量为(9～18)pGy/Bq,有效剂量当量为20.5pSv/Bq。这表明,由大鼠体内分布资料可估算18F-DOPA在人体内的吸收剂量,为临床安全应用18F-DOPA提供了参考资料。
Animals were sacrificed 5, 30, 60, 90, 120 and 150 minutes after the caudal vein injection of 6-18F-DOPA and the distribution of 18F activity in each organ of rats was measured Standard human body distribution, according to MIRD method to estimate the body absorbed within the 18F-DOPA dose. The results showed that the internal absorption dose of kidney was the highest (22.9 pGy / Bq), the internal radiation absorbed dose of brain was 11.8 pGy / Bq, and the internal organs absorbed dose of other organs was (9-18) pGy / Bq. The equivalent weight is 20.5 pSv / Bq. This shows that in vivo distribution of 18F-DOPA can estimate the dose absorbed in the human body, for clinical safe use of 18F-DOPA provides a reference.