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我们以现代科技理论为出发点 ,提出了《组合中药学》新理论体系 ,试图使中外学者对中药的认识趋于一致。中药的本质就是“组合”。无论是单方或复方都是一个庞大的分子库。具有相同或相似功能的分子组合成一个群体。这些群体表现出特定的药效。“组合”有三层意思 :生药的组合、活性分子群的组合与特定疗效的组合。分子群是特定药效功能的物质基础。《组合中药学》就是从《组合分子》水平上研究中药及其药效的物质基础 ,阐明中药活性部位的相互作用与药效的相互关系及其作用机制。《组合中药学》的三个新概念 :中药功效分子族 :具有相似药效作用的一类分子的组合 ,其骨架及功能团相同或相似。单味中药表征性组合分子 :单味中药药效的代表性功效分子族 ,即主要药效分子组合。单味中药非表性组合分子 :单味中药表征性分子以外的其它功效分子族 ,即辅助药效分子的组合。《组合中药学》的主要研究范围 :中药药效的组合分子学基础 (植物化学 ,天然产物 ) ;组合分子的药理学基础 (分子生物学 ,细胞生物学 ,药理学 )。本文提出了应用《组合中药学》研究新型中药的新方法。
Taking modern science and technology theory as a starting point, we proposed a new theoretical system of “combination Chinese pharmacy” and tried to make Chinese and foreign scholars’ understanding of traditional Chinese medicine more consistent. The essence of Chinese medicine is “combination.” Whether unilateral or compound is a huge molecular library. Molecules with the same or similar functions are combined into one group. These groups show specific efficacy. “Combination” has three meanings: a combination of crude drugs, a combination of active molecular groups, and a combination of specific therapeutic effects. Molecular populations are the material basis for specific pharmacodynamic functions. “Combined Chinese Pharmacy” is a study of the material basis of traditional Chinese medicine and its pharmacodynamics from the level of “combined molecules” to elucidate the relationship between the interaction of active parts of traditional Chinese medicines and its efficacy and its mechanism of action. Three new concepts of “combination Chinese pharmacy”: Traditional Chinese medicine efficacy molecular family: A group of molecules with similar pharmacodynamic effects, their skeletons and functional groups are the same or similar. Single Chinese medicine characterizing combinatorial molecules: The representative functional molecular family of pharmacodynamic effects of single Chinese herbs, ie, the main pharmacodynamic molecular combinations. Single-taste non-epitope combination of Chinese medicines: A group of other functional molecules other than the single-taste Chinese medicine-representing molecules, that is, a combination of adjuvant drug molecules. The main research scope of “combination Chinese pharmacy”: the combined molecular basis of pharmacodynamics of traditional Chinese medicine (phytochemistry, natural products); the pharmacology of combinatorial molecules (molecular biology, cell biology, pharmacology). This article proposes a new method for the study of a new type of traditional Chinese medicine using “combination of traditional Chinese medicine”.